Prediction of Porto systemic Collaterals using MR Elastography in Non-alcoholic Fatty Liver Disease
نویسندگان
چکیده
Background and Aim: MR Elastography (MRE) is a non-invasive gold standard to assess liver fibrosis in Non-Alcoholic Fatty Liver Disease (NAFLD). Porto-systemic collaterals (PsC) signify presence of clinically significant portal hypertension (CSPH) & associated with complications variceal hemorrhage, ascites overt encephalopathy. FibroScan shows low sensitivity specificity detect CSPH NAFLD, the aim this study evaluated stiffness (LS) threshold level using MRE for detection PsC indicate NAFLD. Method: 392 NAFLD subjects (257 males, 135 females) undergoing between 2015 2022 were retrospectively analyzed. During sequencing, additional T2 weighted images obtained spleen size PsC. The correlation LS, FIB4 index was determined by Spearman Rank test. ROC analysis cut-offs prediction Result: mean age 47 years ± 13 had median LS score 2.7 kPa± 2.8 kPa. 104 (26.5%) advanced (LSM-5 kPa). Presence significantly correlated (r=0.543, p<0.001) (r=0.478, p<0.001). at cut-off 6.15 kPa (sensitivity-76.9%, specificity-77.1%, AUC=0.87) compared (cut-off-1.98, sensitivity-74.4%, specificity-74.3%, AUC=0.81). A regression model MRE, splenomegaly platelet count showed an accuracy 90.2% whilst index, platelets demonstrated 87% predicting form Conclusion: Elastography, kPa, reliable method hence patients alone combining FIB4-index, similar can be beneficial community settings where MRI may unavailable.
منابع مشابه
Transient elastography in non-alcoholic fatty liver disease.
Non-alcoholic fatty liver disease (NAFLD) is a relevant issue in public health owing to its epidemiological burden. It represents the most common chronic liver disease in the general population and is expected to increase in future as a result of an ageing population. Liver biopsy is still considered the "gold standard" for distinguishing the broad range of NAFLD. However, liver biopsy is often...
متن کاملClinical Manifestations and Diagnosis of Non-Alcoholic Fatty Liver Disease
Background & Objective: Nonalcoholic fatty liver diseases (NAFLD) is the major cause of hepatocellular carcinoma and increases the risk of mortality. Understanding the trends of its clinical and biochemical changes is essential to identify patients with NAFLD that are at the greatest risk of nonalcoholic steatohepatitis (NASH) and cirrhosis in Iran. M...
متن کاملThe Effect of GeriLact on Non-Alcoholic Fatty Liver Disease
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease which is correlated with overweight, obesity, and insulin resistance. Recently, the use of probiotics has been suggested for these patients as they have considerable outcomes. The aim of the present study is to evaluate the effect of GeriLact on patients with NAFLD. Method:</...
متن کاملNon-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease describes a range of conditions caused by a build-up of fat within liver cells. It is very common and in many cases is linked to being obese or overweight. Most people with non-alcoholic fatty liver disease do not develop serious liver problems. In some people, the build-up of fat in the liver can lead to serious liver disease. However, all people with non-alco...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of clinical and experimental hepatology
سال: 2023
ISSN: ['0973-6883', '2213-3453']
DOI: https://doi.org/10.1016/j.jceh.2023.07.171